Niacinamide
Niacinamide is the physiologically active form of vitamin B3 or niacin*. It is a common ingredient in many skin products.
Niacinamide and its derivatives are important parts of many biosynthetic pathways. The coenzymes involved in the usage of niacinamide have been shown to deplete with age. It was also shown that localized increases in niacinamide (ie. topical application) increased intracellular niacinamide coenzymes.
*Niacin, the inactive form, was shown to topically produce flushing.
What does topical application of niacinamide do?
Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.
Niacinamide and its derivatives are important parts of many biosynthetic pathways. The coenzymes involved in the usage of niacinamide have been shown to deplete with age. It was also shown that localized increases in niacinamide (ie. topical application) increased intracellular niacinamide coenzymes.
*Niacin, the inactive form, was shown to topically produce flushing.
What does topical application of niacinamide do?
- increase intracellular niacinamide coenzymes
- stimulate new collagen synthesis
- increase ceramide synthesis leading to increased stratum corneum barrier function
- prevents negative consequences of UV radiation exposure and improves photoaged skin
- Reduces hyper-pigmentation via prevention of melanosome transfer
- Decreases Acne
- via anti-inflammatory properties
- via decrease in sebaceous lipid synthesis (decreases sebaceous oil production that contributes to acne)
Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.
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